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KMID : 0861020080230010063
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Korea Journal of Herbology
2008 Volume.23 No. 1 p.63 ~ p.74
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Effects of Uncooked Korean Food on Blood Glucose and Antioxidant Enzyme Activities of Streptozotocin-induced Diabetic Rats
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Cho Chung-Sik
Song See-Won
Nam Tae-Heung
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Abstract
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Objective: This study has been carried out to understand the effect of Uncooked Korean Food(F-DM)
on blood glucose and antioxidant enzyme activities in streptozotocin-induced Diabetic Rats.
Methods: SD rats were separated into four groups(each with 20 rats). Except normal two group, the
other two groups were injected into intra-peritoneal with streptozotocin 60 ㎎/㎏. Experimental group
was eated Feed with 25% F-DM for 4 weeks. The change of plasma glucose level, body weight were observed. After 4 weeks, liver and kidney weight, antioxidant enzyme activities, survival rate were observed with histological changes on liver, kidney and pancreas.
Results: In experimental group, body weight and survival rate increased, plasma glucose level were
decreased significantly. Liver and kidney weight, XOD activity were decreased in experimental group compared to control group. GSH-px and CAT activities, insulin- immunoreactive granules in β-cells were increased significantly in experimental group compared to control group.
Conclusions: This study shows that the F-DM might be effective for treatment of diabetes and its
complications, as well as reduction of the oxidative stress.
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KEYWORD
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Diabetes mellitus, Uncooked Korean Food(F-DM), streptozotocin, oxidative stress, insulin-immunoreactive granules
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